Publications

  1. Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ. Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. Biophys J. 2017 Feb 28; 112(4):736-745. PMID: 28256233.

    View in: PubMed 

  2. Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD. SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73. Cell Signal. 2016 Dec; 28(12):1923-1932. PMID: 27705752.

    View in: PubMed 

  3. Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Res Treat. 2016 Jun; 157(2):351-361. PMID: 27146587.

    View in: PubMed 

  4. Gascard P, Tlsty TD. Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes Dev. 2016 05 01; 30(9):1002-19. PMID: 27151975; PMCID: PMC4863733 [Available on 11/01/16].

    View in: PubMed, PubMed Central 

  5. Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep. 2015 Oct 16; 5:15153. PMID: 26472542; PMCID: PMC4608012.

    View in: PubMed, PubMed Central 

  6. Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF. Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. Org Biomol Chem. 2015 Dec 07; 13(45):11078-86. PMID: 26400105; PMCID: PMC4644089 [Available on 12/07/16].

    View in: PubMed, PubMed Central

  7. Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. PMID: 25693563; PMCID: PMC4530010.

    View in: PubMed, PubMed Central 

  8. Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF. Intermediate DNA methylation is a conserved signature of genome regulation. Nat Commun. 2015 Feb 18; 6:6363. PMID: 25691127; PMCID: PMC4333717.

    View in: PubMed, PubMed Central 

  9. Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015 Feb 18; 6:6351. PMID: 25690954; PMCID: PMC4346612.

    View in: PubMed, PubMed Central 

  10. Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB. Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nat Commun. 2014 Nov 25; 5:5442. PMID: 25421844; PMCID: PMC4385735.

    View in: PubMed, PubMed Central 

  11. DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD. Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res. 2014 Sep 15; 74(18):5032-44. PMID: 25172842; PMCID: PMC4335659.

    View in: PubMed, PubMed Central

  12. Wu A, Liao D, Tlsty TD, Sturm JC, Austin RH. Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment. Interface Focus. 2014 Aug 06; 4(4):20140028. PMID: 25097749; PMCID: PMC4071511.

    View in: PubMed, PubMed Central 

  13. Liao D, Tlsty TD. Evolutionary game theory for physical and biological scientists. I. Training and validating population dynamics equations. Interface Focus. 2014 Aug 06; 4(4):20140037. PMID: 25097751; PMCID: PMC4071513.

    View in: PubMed, PubMed Central 

  14. Liao D, Tlsty TD. Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations. Interface Focus. 2014 Aug 06; 4(4):20140038. PMID: 25097752; PMCID: PMC4071514.

    View in: PubMed, PubMed Central 

  15. Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC. Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16103-8. PMID: 24046372; PMCID: PMC3791735.

    View in: PubMed, PubMed Central 

  16. Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T. Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res. 2013 Sep; 23(9):1522-40. PMID: 23804400; PMCID: PMC3759728.

    View in: PubMed, PubMed Central 

  17. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41. PMID: 23708189; PMCID: PMC3695047.

    View in: PubMed, PubMed Central 

  18. López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM. Coordinate transcriptional and translational repression of p53 by TGF-ß1 impairs the stress response. Mol Cell. 2013 May 23; 50(4):552-64. PMID: 23706820; PMCID: PMC3735454.

    View in: PubMed, PubMed Central 

  19. Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4598-603. PMID: 23487770; PMCID: PMC3607035.

    View in: PubMed, PubMed Central 

  20. Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD. Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia. 2013 Mar; 15(3):249-62. PMID: 23479504; PMCID: PMC3593149.

    View in: PubMed, PubMed Central

  21. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. PMID: 23618955; PMCID: PMC3636513.

    View in: PubMed, PubMed Central 

  22. Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD. Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Res. 2012 Dec 07; 14(6):R155. PMID: 23216814; PMCID: PMC3786321.

    View in: PubMed, PubMed Central 

  23. DeFilippis RA, Tlsty TD. Hello out there...is anybody listening? Cancer Discov. 2012 Dec; 2(12):1084-6. PMID: 23230186; PMCID: PMC4326255.

    View in: PubMed, PubMed Central

  24. Liao D, Estévez-Salmerón L, Tlsty TD. Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065006. PMID: 23197162; PMCID: PMC3618713.

    View in: PubMed, PubMed Central 

  25. Liao D, Estévez-Salmerón L, Tlsty TD. Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol. 2012 Dec; 9(6):065005. PMID: 23197078; PMCID: PMC3618714.

    View in: PubMed, PubMed Central 

  26. DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov. 2012 Sep; 2(9):826-39. PMID: 22777768; PMCID: PMC3457705.

    View in: PubMed, PubMed Central 

  27. Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 2012 Apr 04; 486(7403):395-9. PMID: 22495314; PMCID: PMC3863681.

    View in: PubMed, PubMed Central 

  28. Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC. p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila). 2011 Dec; 4(12):1953-60. PMID: 21920875; PMCID: PMC3232312.

    View in: PubMed, PubMed Central 

  29. Tlsty TD. Tissue states provide novel insights into attributes that drive metastasis. Cancer Cell. 2011 Sep 13; 20(3):285-6. PMID: 21907919.

    View in: PubMed 

  30. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. PMID: 21480238; PMCID: PMC3277953.

    View in: PubMed, PubMed Central

  31. Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer. 2011 05; 11(5):375-82. PMID: 21508974; PMCID: PMC3488437.

    View in: PubMed, PubMed Central 

  32. Tlsty TD. A twist of cell fate. Cell Stem Cell. 2011 Feb 04; 8(2):126-7. PMID: 21295267.

    View in: PubMed

  33. Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst. 2010 May 05; 102(9):627-37. PMID: 20427430; PMCID: PMC2864293.

    View in: PubMed, PubMed Central 

  34. Berman HK, Gauthier ML, Tlsty TD. Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prev Res (Phila). 2010 May; 3(5):579-87. PMID: 20424132.

    View in: PubMed

  35. McDermott KM, Liu BY, Tlsty TD, Pazour GJ. Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol. 2010 Apr 27; 20(8):731-7. PMID: 20381354; PMCID: PMC2916967.

    View in: PubMed, PubMed Central

  36. Blackburn EH, Tlsty TD, Lippman SM. Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila). 2010 Apr; 3(4):394-402. PMID: 20354163.

    View in: PubMed

  37. Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prev Res (Phila). 2010 Feb; 3(2):190-201. PMID: 20028875; PMCID: PMC2954106.

    View in: PubMed, PubMed Central

  38. Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD. Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res. 2009; 11(6):R87. PMID: 19995452; PMCID: PMC2815551.

    View in: PubMed, PubMed Central

  39. Dumont N, Tlsty TD. Reflections on miR-ing effects in metastasis. Cancer Cell. 2009 Jul 07; 16(1):3-4. PMID: 19573805.

    View in: PubMed

  40. Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):14867-72. PMID: 18806226; PMCID: PMC2567459.

    View in: PubMed, PubMed Central

  41. Chang H, DeFilippis RA, Tlsty TD, Parvin B. Graphical methods for quantifying macromolecules through bright field imaging. Bioinformatics. 2009 Apr 15; 25(8):1070-5. PMID: 18703588; PMCID: PMC2666809.

    View in: PubMed, PubMed Central

  42. Tlsty T. Cancer: whispering sweet somethings. Nature. 2008 May 29; 453(7195):604-5. PMID: 18509432.

    View in: PubMed 

  43. Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL. Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF. Clin Cancer Res. 2007 Nov 15; 13(22 Pt 1):6834-41. PMID: 18006786.

    View in: PubMed

  44. Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD. Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell. 2007 Nov; 12(5):479-91. PMID: 17996651; PMCID: PMC3605202.

    View in: PubMed, PubMed Central

  45. Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ, Reynolds CA, Hartmann LC. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol. 2007 Jul 01; 25(19):2671-7. PMID: 17563394.

    View in: PubMed 

  46. Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR. Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. Cell Cycle. 2007 Aug 01; 6(15):1927-36. PMID: 17671422.

    View in: PubMed

  47. Tlsty TD. Luminal cells GATA have it. Nat Cell Biol. 2007 Feb; 9(2):135-6. PMID: 17268476.

    View in: PubMed

  48. Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD. p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Res. 2006 Nov 01; 66(21):10325-31. PMID: 17079452.

    View in: PubMed

  49. Grant MR, Mostov KE, Tlsty TD, Hunt CA. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol. 2006 Oct 06; 2(10):e129. PMID: 17029556; PMCID: PMC1592363.

    View in: PubMed, PubMed Central

  50. Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem. 2006 Aug 25; 281(34):24790-802. PMID: 16766534.

    View in: PubMed

  51. McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 2006 Mar; 4(3):e51. PMID: 16464125; PMCID: PMC1361797.

    View in: PubMed, PubMed Central

  52. Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol. 2006; 1:119-50. PMID: 18039110.

    View in: PubMed

  53. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ, Visscher DW. Benign breast disease and the risk of breast cancer. N Engl J Med. 2005 Jul 21; 353(3):229-37. PMID: 16034008.

    View in: PubMed 

  54. Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res. 2005 Mar 01; 65(5):1792-9. PMID: 15753376.

    View in: PubMed

  55. Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz K, Tlsty TD. Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis. Cold Spring Harb Symp Quant Biol. 2005; 70:317-27. PMID: 16869768.

    View in: PubMed

  56. Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, McDermott K, Kozakiewicz K, Gauthier ML. Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis. J Mammary Gland Biol Neoplasia. 2004 Jul; 9(3):263-74. PMID: 15557799.

    View in: PubMed

  57. Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell. 2004 Mar; 5(3):263-73. PMID: 15050918.

    View in: PubMed

  58. Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew KL, Moore DH, Cha I, Tlsty TD, Esserman LJ. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res. 2003 May 15; 63(10):2347-50. PMID: 12750248.

    View in: PubMed

  59. Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res. 2003 Apr 01; 63(7):1596-601. PMID: 12670910.

    View in: PubMed

  60. Tlsty TD. Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer. Cancer Cell. 2002 Jul; 2(1):2-4. PMID: 12150817.

    View in: PubMed

  61. Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M. Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Exp Cell Res. 2002 Feb 01; 273(1):21-33. PMID: 11795943.

    View in: PubMed

  62. Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD. Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer. Clin Cancer Res. 2001 Sep; 7(9):2712-8. PMID: 11555583.

    View in: PubMed

  63. Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH. DNA replication licensing and human cell proliferation. J Cell Sci. 2001 Jun; 114(Pt 11):2027-41. PMID: 11493639.

    View in: PubMed 

  64. Tlsty TD, Romanov SR, Kozakiewicz BK, Holst CR, Haupt LM, Crawford YG. Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence. J Mammary Gland Biol Neoplasia. 2001 Apr; 6(2):235-43. PMID: 11501583.

    View in: PubMed

  65. Tlsty TD. Stromal cells can contribute oncogenic signals. Semin Cancer Biol. 2001 Apr; 11(2):97-104. PMID: 11322829.

    View in: PubMed

  66. Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 2001 Feb 01; 409(6820):633-7. PMID: 11214324.

    View in: PubMed

  67. Tlsty TD. Searching for targets: the power of somatic cell genetics. Genome Res. 2001 Feb; 11(2):187-8. PMID: 11157780.

    View in: PubMed

  68. Tlsty TD, Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 2001 Feb; 11(1):54-9. PMID: 11163151.

    View in: PubMed

  69. Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10544-8. PMID: 10962037; PMCID: PMC27061.

    View in: PubMed, PubMed Central

  70. Meyer KM, Hess SM, Tlsty TD, Leadon SA. Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light. Oncogene. 1999 Oct 14; 18(42):5795-805. PMID: 10523860.

    View in: PubMed

  71. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999 Oct 01; 59(19):5002-11. PMID: 10519415.

    View in: PubMed 

  72. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999 Jan; 21(1):111-4. PMID: 9916802.

    View in: PubMed

  73. Tlsty TD. A molecular blueprint for targeting cancer? Nat Genet. 1999 Jan; 21(1):64-5. PMID: 9916789.

    View in: PubMed

  74. Olumi AF, Dazin P, Tlsty TD. A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death. Cancer Res. 1998 Oct 15; 58(20):4525-30. PMID: 9788594.

    View in: PubMed

  75. Tlsty TD. Cell-adhesion-dependent influences on genomic instability and carcinogenesis. Curr Opin Cell Biol. 1998 Oct; 10(5):647-53. PMID: 9818176.

    View in: PubMed

  76. Hayward SW, Grossfeld GD, Tlsty TD, Cunha GR. Genetic and epigenetic influences in prostatic carcinogenesis (review). Int J Oncol. 1998 Jul; 13(1):35-47. PMID: 9625801.

    View in: PubMed

  77. Gonzales AJ, Christensen JG, Preston RJ, Goldsworthy TL, Tlsty TD, Fox TR. Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital. Carcinogenesis. 1998 Jul; 19(7):1173-83. PMID: 9683175.

    View in: PubMed

  78. Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD. An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5166-71. PMID: 9560247; PMCID: PMC20232.

    View in: PubMed, PubMed Central

  79. Hall IJ, Gioeli D, Weissman BE, Tlsty TD. Identification of additional complementation groups that regulate genomic instability. Genes Chromosomes Cancer. 1997 Oct; 20(2):103-12. PMID: 9331561.

    View in: PubMed

  80. Nigro JM, Aldape KD, Hess SM, Tlsty TD. Cellular adhesion regulates p53 protein levels in primary human keratinocytes. Cancer Res. 1997 Sep 01; 57(17):3635-9. PMID: 9288761.

    View in: PubMed

  81. Tlsty TD. Genomic instability and its role in neoplasia. Curr Top Microbiol Immunol. 1997; 221:37-46. PMID: 8979439.

    View in: PubMed

  82. Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB. Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. Cancer Res. 1996 Aug 15; 56(16):3659-62. PMID: 8706003.

    View in: PubMed

  83. Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD. Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. J Virol. 1996 Feb; 70(2):999-1008. PMID: 8551641; PMCID: PMC189905.

    View in: PubMed, PubMed Central

  84. Tlsty TD. Regulation of genomic instability in preneoplastic cells. Cancer Surv. 1996; 28:217-24. PMID: 8977037.

    View in: PubMed

  85. Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A. Genomic instability and cancer. Mutat Res. 1995 Jul; 337(1):1-7. PMID: 7596354.

    View in: PubMed

  86. Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res. 1995 Apr 15; 55(8):1763-73. PMID: 7712486.

    View in: PubMed

  87. Tlsty T, Briot A, Poulose B. Analysis of cell cycle checkpoint status in mammalian cells. Methods Enzymol. 1995; 254:125-33. PMID: 8531681.

    View in: PubMed

  88. Forrester K, Kispert J, Sanchez JH, Gerwin BI, Tlsty TD, Harris CC. Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification. Mol Carcinog. 1994 Sep; 11(1):34-41. PMID: 7916988.

    View in: PubMed

  89. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994 Mar 25; 76(6):1013-23. PMID: 8137420.

    View in: PubMed

  90. White AE, Livanos EM, Tlsty TD. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev. 1994 Mar 15; 8(6):666-77. PMID: 7926757.

    View in: PubMed

  91. Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A, Poulose B. Genomic integrity and the genetics of cancer. Cold Spring Harb Symp Quant Biol. 1994; 59:265-75. PMID: 7587078.

    View in: PubMed

  92. Schaefer DI, Livanos EM, White AE, Tlsty TD. Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts. Cancer Res. 1993 Oct 15; 53(20):4946-51. PMID: 8402685.

    View in: PubMed

  93. Jonczyk P, White A, Lum K, Barrett JC, Tlsty TD. Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens. Cancer Res. 1993 Jul 01; 53(13):3098-102. PMID: 8319217.

    View in: PubMed

  94. Tlsty TD, Jonczyk P, White A, Sage M, Hall I, Schaefer D, Briot A, Livanos E, Roelofs H, Poulose B, et al. Loss of chromosomal integrity in neoplasia. Cold Spring Harb Symp Quant Biol. 1993; 58:645-54. PMID: 7956081.

    View in: PubMed

  95. Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 1992 Sep 18; 70(6):923-35. PMID: 1356076.

    View in: PubMed

  96. Tlsty TD, White A, Sanchez J. Suppression of gene amplification in human cell hybrids. Science. 1992 Mar 13; 255(5050):1425-7. PMID: 1542791.

    View in: PubMed

  97. Tlsty TD, Adams P. Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line. Exp Cell Res. 1990 May; 188(1):164-8. PMID: 2328775.

    View in: PubMed

  98. Tlsty TD. Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3132-6. PMID: 2326271; PMCID: PMC53848.

    View in: PubMed, PubMed Central

  99. Tlsty TD, Margolin BH, Lum K. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9441-5. PMID: 2687881; PMCID: PMC298512.

    View in: PubMed, PubMed Central

  100. Goz B, Carl PL, Tlsty TD. 1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells. Mol Pharmacol. 1989 Sep; 36(3):360-5. PMID: 2571071.

    View in: PubMed

  101. Otto E, McCord S, Tlsty TD. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. J Biol Chem. 1989 Feb 25; 264(6):3390-6. PMID: 2914957.

    View in: PubMed

  102. Rath H, Tlsty T, Schimke RT. Rapid emergence of methotrexate resistance in cultured mouse cells. Cancer Res. 1984 Aug; 44(8):3303-6. PMID: 6744265.

    View in: PubMed

  103. Tlsty TD, Brown PC, Schimke RT. UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Mol Cell Biol. 1984 Jun; 4(6):1050-6. PMID: 6738530; PMCID: PMC368872.

    View in: PubMed, PubMed Central

  104. Tlsty TD, Albertini AM, Miller JH. Gene amplification in the lac region of E. coli. Cell. 1984 May; 37(1):217-24. PMID: 6327052.

    View in: PubMed

  105. Brown PC, Tlsty TD, Schimke RT. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol Cell Biol. 1983 Jun; 3(6):1097-107. PMID: 6877240; PMCID: PMC368639.

    View in: PubMed, PubMed Central

  106. Albertini AM, Hofer M, Calos MP, Tlsty TD, Miller JH. Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli. Cold Spring Harb Symp Quant Biol. 1983; 47 Pt 2:841-50. PMID: 6345079.

    View in: PubMed

  107. Berg DE, Egner C, Hirschel BJ, Howard J, Johnsrud L, Jorgensen RA, Tlsty TD. Insertion, excision, and inversion of Tn5. Cold Spring Harb Symp Quant Biol. 1981; 45 Pt 1:115-23. PMID: 6271454.

    View in: PubMed

  108. Tlsty TD, Lieberman MW. The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene. Nucleic Acids Res. 1978 Sep; 5(9):3261-73. PMID: 704356; PMCID: PMC342247.

    View in: PubMed, PubMed Central 

  109. Smerdon MJ, Tlsty TD, Lieberman MW. Distribution of ultraviolet-induced DNA repair synthesis in nuclease sensitive and resistant regions of human chromatin. Biochemistry. 1978 Jun 13; 17(12):2377-86. PMID: 678515.

    View in: PubMed

  110. Wilkinson DS, Tlsty TD, Hanas RJ. The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. Cancer Res. 1975 Nov; 35(11 Pt 1):3014-20. PMID: 171060.

    View in: PubMed